For example, Matboli et al. showed that isorhamnetin used at three different doses (10, 20, 40 mg/kg for 3 weeks) possessed anti-diabetic action by regulating the insulin pathway at the microscopic, molecular and protein levels in the streptozotocin/high fat diet-induced T2DM rat models [89]. Here, INS is linked to type 2 diabetes mellitus.