Exceptions to this are the negative correlation of maternal third trimester activated ghrelin levels with cord blood insulin levels reported by Valsamakis et al. and the reported correlation of cord blood C peptide levels with maternal leptin in early pregnancy and at 28 weeks reported by Walsh et al. However, other studies suggest that the cord blood lipidome and metabolome are sensitive to the intrauterine environment as confirmed in pregnancies complicated by obesity, gestational diabetes or hypercholesterolemia [79,80,81,82] as well as maternal dietary patterns [83]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.