Baraitser-Winter Syndrome (B-WS, OMIM #243310, #614583) is a rare, multiple-anomaly genetic disorder caused by mutations in either cytoplasmically expressed actin gene, <i>ACTB</i> (β-actin) or <i>ACTG1</i> (γ-actin). The gene discussed is ACTB; the disease is Baraitser-Winter cerebrofrontofacial syndrome.