In osteosarcoma cells, SPON1 promotes cell migration and invasion [45], whereas SPON1 exhibits an antioncogenic roles in some tumors: SPON1 expression is negatively correlated with survival in bladder cancer [46], SPON1 mediates the apoptotic effect of anticancer reagent in uterine endometrial cancer cells [47], and SPON1 suppression leads to proliferation, migration, and invasion in hepatocellular carcinoma [48]. Here, SPON1 is linked to hepatocellular carcinoma.