SPARC is highly expressed in GBM, where it promotes the migratory and invasive behavior of glioma cells [62]; moreover, by suppressing tumor vascularity, through the abrogation of VEGFA expression and inhibition of VEGFR2 phosphorylation, it inhibited glioma growth and VEGF-induced DNA synthesis [63]. The gene discussed is SPARC; the disease is glioblastoma.