Downregulation of the TRPML2 channel impaired survival and proliferation, as well as triggered DNA damage and apoptosis, through caspase-3 activation and the blockade of Akt and Erk1/2 phosphorylation, suggesting a pro-tumorigenic role for TRPML2 in glioma progression [2]. This evidence concerns the gene MCOLN2 and glioma.