MCOLN2 and glioblastoma: In this regard, we have demonstrated that the silencing of TRPML2 mRNA in T98 and U251 results in the increase in the DOX sensitivity (IC50: from 9.7 to 21.0 and from 1.0 to 3.0 μM in T98 and U251, respectively), suggesting that high levels of the TRPML2 channel contributes to DOX resistance in GBM cells.