The roles of TyR1175 in ERK-dependent proliferation, Akt activation and migration [40] and inhibition of TyR1175 VEGFR2 we observed in siTRPML2 T98 and U251 cells are in agreement with our previously reported data on the inhibition of ERK-dependent proliferation and AKT activation in siTRPML2 GBM cell lines [2]. This evidence concerns the gene KDR and glioblastoma.