NR3C1 and type 2 diabetes mellitus: In keeping with the possible effect of GR single nucleotide polymorphisms on GC target tissue in eucortisolemic subjects, in postmenopausal women without cortisol excess the N363S GR single nucleotide polymorphism was directly associated with the risk of being affected by two of the following: type 2 diabetes, hypertension and bone fragility [18].