Importantly, lower IGF-I levels six months after recovery from Cushing’s syndrome were found to be associated with adverse long-term myopathy [115], and an inverse correlation between skeletal muscle mass (as evaluated by magnetic resonance imaging) in remission from Cushing’s syndrome and duration of postoperative oral GC administration was suggested [116]. The gene discussed is IGF1; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.