In this study on frozen tissue of 59 adrenal tumors with known genetic background, the authors showed that that transcriptome analysis (gene expression, long noncoding RNA expression and gene fusions) identified two different clusters for adrenal adenomas, the first one mainly consisting of adenomas with mHC and not functioning adrenal adenomas with CTNNB1 or without identified driver mutations, the second one including adenoma with Cushing’s syndrome with or without identified driver mutations. Here, CTNNB1 is linked to Cushing syndrome due to macronodular adrenal hyperplasia.