The condition of pituitary mHC, because of its clinically silent nature, must not be confused with the condition of silent corticotroph adenomas, which, at variance, are defined as ACTH-expressing pituitary tumors that lack both the clinical symptoms of Cushing’s syndrome and evidence of autonomous ACTH secretion [28]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.