Interestingly, in subjects with normal cortisol secretion, the combined estimate of cortisol secretion, cortisone-to-cortisol peripheral activation by the 11 beta-hydroxysteroid dehydrogenase (11BHSD) enzymes and GC receptor (GR) sensitizing variants have been suggested to be associated with the presence of hypertension, diabetes and bone fragility, which are three well-known consequences of hypercortisolism [17,18]. The gene discussed is NR3C1; the disease is hypertensive disorder.