NR3C1 and Cushing syndrome due to macronodular adrenal hyperplasia: Indeed, while a study showed a higher BclI variant prevalence in Cushing’s syndrome [65], other data did not confirm this association, showing that the GR gene nucleotide polymorphisms BclI, N363S, ER22/23EK and A3669G did not influence the development of both pituitary and adrenal Cushing’s syndrome [66,67].