In mouse models of high-fat diet (HFD) and high-fat high-cholesterol (HFCF) diet, increasing HNF4α expression protected against NASH by reducing expression of genes involved in inflammation, fibrogenesis and senescence (e.g., TNFα, IL6, IL1b, MCP1, F4/80 and p53), liver injury and ROS production. This evidence concerns the gene TP53 and metabolic dysfunction-associated steatohepatitis.