Mechanically, myocyte-derived Hsp90 regulates interleukin-6 (IL-6) synthesis and its release in exosomal vesicles, which are responsible for the activation of Signal Transducer And Activator Of Transcription 3 (STAT-3) signalling in cardiac fibroblasts and subsequent excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy [47]. This evidence concerns the gene HSP90AA1 and cardiac hypertrophy.