The involvement of the Hippo pathway in the regulation of the apoptotic process resulting from the metabolic changes associated with type 2 diabetes has been documented on the basis of the contribution of its individual elements, including MST1 [64], Merlin (Nf2) [65], LATS2 [46,66], and YAP [65,67]. The gene discussed is MST1; the disease is type 2 diabetes mellitus.