IAPP and digestive system neoplasm: Glucotoxicity, lipotoxicity [17,18,19,20], endoplasmatic reticulum (ER) stress [21,22], oxidative stress [23,24], islet amyloid polypeptide (IAPP) [25], and inflammation [15,26] and are responsible for the loss of pancreatic mass, leading to progressive β-cell failure of the pancreas in type 2 diabetes [19,27,28].