Other coexisting neurological disorders such as Alzheimer’s disease, Parkinson’s disease and exposure to neurotoxic stimulus cause damage to the BBB that along with tau and NFT aggregation, α synuclein and Aβ deposition and the presence of damage-associated molecular pattern (DAMP) and pathogen-associated molecular pattern molecules (PAMPs) result in NLRP3, TLR-4 and microglial activation, macrophage infiltration and nuclear translocation of NF-kB [133]. This evidence concerns the gene NLRP3 and Alzheimer disease.