XIST and neoplasm: Recently, complex lncRNA/miRNA/mRNA networks based on XIST/miR-500a-3p, miR-370-3p, miR-2467-3p, miR-512-3p/XBP have been demonstrated to promote cell proliferation and aggravated tumor growth in vivo by regulating endoplasmic reticulum stress response and cell apoptosis [67].