Similarly to ZEB2, ZEB1 from the same protein family has also been linked to an oncogenic role of XIST in another kind of tumor: in pancreatic cancer, XIST was frequently upregulated, especially in metastatic tissues, and sponges the tumor suppressor miR-429, thus acting as a ceRNA for ZEB1 that was upregulated; in particular, the axis XIST/miR-429/ZEB1 is critical for cell migration, invasion and EMT [71]. Here, ZEB2 is linked to familial pancreatic carcinoma.