XIST and malignant colon neoplasm: In the case of colon cancer, the studies consistently point to an oncogenic role of XIST: it was upregulated in colon cancer tissues compared to the non-tumoral tissues and correlated to poor prognosis; it sponges miR-34a, thus preventing miRNA binding to WNT1, thus triggering the Wnt/beta-catenin pathway activation and then promoting proliferation and invasion of colon cancer cells [64].