Both ZEB1 and 2 have also been found to be involved in retinoblastoma, the most frequent eye malignancy in childhood, where XIST’s oncogenic role has been demonstrated in terms of promotion of proliferation, migration, invasion and EMT; again, XIST acts as a sponge for miR-101, thus resulting in the upregulation of its targets ZEB1 and ZEB2 [73]. This evidence concerns the gene XIST and retinoblastoma.