FTX and hepatocellular carcinoma: It has been suggested that the tumor suppressor role and the reported expression pattern of FTX may contribute to HCC gender disparity, to date attributed solely to sex hormones: males are more susceptible than females to HCC, with average ratios between 2:1 and 4:1 [195,196]; in addition, male HCC patients suffer even worse prognoses than females patients and have shorter survival.