FTX and hepatocellular carcinoma: In particular, in HCC FTX inhibits proliferation and metastasis both in vitro and in vivo by repressing the silencing activity of miR-374a on its targets, i.e., WIF1, PTEN and WNT5A, as negative regulators of the WNT/beta-catenin signaling cascade, that indeed were inhibited, thus promoting cell epithelial–mesenchymal transition and invasion.