PTEN and neoplasm: In particular, FTX interacted with DHX9 and Dicer and regulated A-to-I RNA editing and miRNA expression; miR-374b and miR-545 repressed tumor suppressors PTEN and RIG-I to increase proto-oncogenic PI3K-AKT signaling; miR-421 may have an autoregulatory effect on miR-374b and miR-545 [193].