Vice versa, the same mRNAs in combination with different XIST/miRNA axes can have relevance in different pathological contexts; as an example, the ZEB1/ZEB2 family has been implicated in NSCLC, pancreatic cancer, retinoblastoma and HCC in combination with different XIST/miRNA axes [71,72,74,104], as shown in Table 1. This evidence concerns the gene ZEB2 and familial pancreatic carcinoma.