CALR and neoplasm: The increased expression of both CD47 and CALR on tumor cells surface raised the hypothesis that, on one hand, CALR is essential for anti-CD47 antibody-mediated phagocytosis and, on the other hand, increased CD47 expression prevents tumor cells from CALR-mediated phagocytosis, contributing to pro- and anti-phagocytic balance underlying the immune evasion mechanism [110].