INS and Hyperglycemia: Among both lean and obese participants, the overall (area under the curve) insulin clearance rate during constant hyperglycemia or sequential graded glucose infusion with glucose infusion rates ranging from zero to 8 mg/kg body mass/min was less in participants who were insulin resistant compared to those who were insulin sensitive; in addition, insulin clearance correlated positively with insulin sensitivity [76,88,89,90,92].