However, the results from studies that provided a comprehensive analysis of the relationships among insulin secretion in response to glucose ingestion and hepatic, extrahepatic, and whole-body insulin plasma clearance and tissue extraction rates suggest that NAFLD does not impair hepatic insulin extraction per se, but rather the lower hepatic and whole-body insulin clearance in people with NAFLD are due to insulin resistance and insulin hypersecretion [84,95]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.