Plasma insulin clearance in people with obesity and T2D has been assessed by using an intravenous glucose tolerance test, an insulin-modified intravenous glucose tolerance test, an insulin suppression test, a hyperinsulinemic or hyperglycemic clamp procedure, an oral glucose tolerance test, and mixed meal tests [3,8,27,83,84,85,86,87,88,89,90,91,92,93,94,95,96]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.