Endogenous depletion of FAT1 under hypoxic conditions was accompanied by a decrease in HIF-1α expression, along with its downstream target genes (CA9, GLUT1, VEGFA, MCT4, HK2, BNIP3, and REDD1) [95]; the result was an important diminution in the GBM’s aggressiveness. The gene discussed is FAT1; the disease is glioblastoma.