Moreover, Bartrons et al. demonstrated that there is a metabolic reprogramming of tumoral cells by the cross-transfer of lactate from cancer-associated fibroblasts (whose metabolism takes place in hypoxic conditions where ROS, HIF-1α, and NF-κB induce glycolysis) to cancer cells where the lactate is transformed to pyruvate and consumed in the TCA cycle. This evidence concerns the gene HIF1A and cancer.