HIF1A and neoplasm: In different types of solid tumors, researchers have indicated the implications of HIF-1α in the regulation of EMT transcription factors, enzymes (e.g., lysyl oxidase (LOX)), MMPs (such as collagenase MMP1 and gelatinase MMP2), histone modifiers (e.g., histone lysine-specific demethylase 4B (KDM4B)), adhesion molecules (e.g., angiopoietin-like 4 (ANGPTL4), L1 cell adhesion molecule (L1CAM)), chemokine receptors 1 and 4 (CX3CR1, CXCR4), and miRNA targets to stimulate tumor progression and invasion [148,149].