Postic et al. investigated the effect of PEG 200, 2000, and 20,000, and poly(vinyl pyrrolidone) 8000 on membrane transport apoptotic markers, cell viability by PrestoBlue assay, cell morphology, and caspase 3/7 activity on metastatic melanoma A375, mouse fibroblast 3T3, and human corneal epithelial cells [41]. This evidence concerns the gene CASP3 and metastatic melanoma.