CCR8 and glioblastoma: In addition, the delivery of glioblastoma (GBM) cell-derived EVs to the recipient GBM cells was shown to involve a triple interaction between the chemokine receptor CCR8 expressed on cells, the glycans exposed on GBM-derived EVs, and the soluble ligand CCL18, which, in turn, promoted the proliferation of GBM cells and resistance to the alkylating agent temozolomide [76].