NRP1 and central nervous system cancer: Jia et al. conjugated neuropilin-1 (NRP-1) targeting peptide (RGE peptide) to the exosomal membrane using click chemistry, which promoted glioma targeting and BBB penetration in orthotopic glioma models since NRP-1 was reported to be overexpressed in glioma cells and tumor vascular endothelium [85,86].