LRRC8A and ovarian carcinoma: Presumably, LRRC8A forming VSOR/VSOAC is required for an increase in the level of p53 protein and an increase in the level of its downstream signaling elements, i.e., MDM2 and p21Waf1/Cip1 expression, and cisplatin-induced caspase-9 and -3 activation in A2780 human ovarian cancer cells, such as and in A549 alveolar carcinoma cells, as pharmacological inhibition and transient knockdown of LRRC8A inhibited these processes [78].