NPM1 and chronic myelomonocytic leukemia: Another study by Vallapureddy et al. observed some of the same characteristics—notably, more severe anemia in NPM1-mutated CMML patients—and additionally described that DNMT3A and FLT3 mutations were more common, while TET2 and ASXL1 mutations were less common than in CMML cases with no NPM1 mutation [120].