A study of 144 CMML patients by Peng et al. described that NPM1-mutated CMML cases were characterized by more severe anemia, higher BM monocyte percentage, a more rapid transformation to AML, and decreased overall survival (OS) then non-NPM1-mutated cases, though this study did not reach statistical significance [119]. The gene discussed is NPM1; the disease is acute myeloid leukemia.