NPM1 and acute myeloid leukemia: Though it is clear that the presence of FLT3-ITD mutations negatively influence the prognosis, it is to be pointed out that in younger adult patients, the prognosis is still better than in those patients who have AML with FLT3-ITD and wild-type NPM1, especially when the FLT3-ITD mutation is present at a low allelic ratio [65,66,67].