PRDM1 and aggressive NK-cell leukemia: ENKTL showed a recurrent gain of 2q33.1–q37.3 containing WNT6; gain of 17q21.2–q21.31 containing STAT3/5B/5A; loss of 1p36.23–p36.33 containing PRDM1; loss of 2p16.1–p16.3 containing BIN1; loss of 4q12 containing KIT; loss of 4q31.3–q32.1 containing PDGFC; and loss of 5p14.1–p14.3, 5q34–q35.3, and 6q21–q22.1 containing FOXO3, HACE1, PRDM1, ATG5, and AIM1, while aggressive NK cell leukemia showed more frequent gains of 1q23.1–q24.2 and 1q31.3–q44, as well as losses of 7p15.1–p22.3 and 17p13.1 containing TP53.