While the somatic variants in KRAS, NRAS, PTPN1, NF1 (Neurofibromin 1), and CBL involved in RAS/MAPK pathway are frequent in different types of cancers, germline variants in these genes are associated with a diverse group of congenital disorders (neurofibromatosis type 1, cardiofaciocutaneous syndrome, Costello syndrome, Noonan syndrome, and Noonan syndrome with multiple lentigines), often referred to as ‘RASopathies’. Here, NF1 is linked to cardiofaciocutaneous syndrome.