The additional concurrent somatic mutations in ASXL1 (ASXL Transcriptional Regulator 1), EZH2, SRSF2 (Serine And Arginine Rich Splicing Factor 2), CUX1 (Cut like homeobox 1), and SETBP1 have also been reported as being strongly associated with secondary AML rather than de novo AML [26]. Here, ASXL1 is linked to acute myeloid leukemia.