The additional concurrent somatic mutations in ASXL1 (ASXL Transcriptional Regulator 1), EZH2, SRSF2 (Serine And Arginine Rich Splicing Factor 2), CUX1 (Cut like homeobox 1), and SETBP1 have also been reported as being strongly associated with secondary AML rather than de novo AML [26]. The gene discussed is CUX1; the disease is acute myeloid leukemia.