One study compared 35 first depressive episode and drug-naïve MDD patients with 35 age- and sex-matched healthy controls, and found that IL-1β was inversely correlated with FA values in the bilateral inferior fronto-occipital fasciculus, left uncinate fasciculus, and genu of the corpus collosum in the MDD group [27]. The gene discussed is IL1B; the disease is major depressive disorder.