PDK3 and cancer: Increase in Pyruvate kinase M2 (PKM2), inducible Nitric Oxide Synthase (iNOS), and glycolytic genes (i.e., SLC2A1, SLC2A4, HK1, HK2, PFKFB3, PDK3, and LDHA). Glycolytic metabolism was observed to increase in EOC cells in comparison with non-cancer cells.