Most of the genes that were hypermethylated in the pathways in cancer were APC, CTBP2, NFKBIA, SMAD2, COL4A1, CDK6, DAPK2, FGF12, FGF14, FGF21, IGF1R, LAMB3, as well as PIK3R1. The gene discussed is COL4A1; the disease is cancer.