In univariate analyses, adverse composite outcome correlated with malignancy(p = 0.002), thrombophilia (p = 0.021), RV dysfunction (p = 0.002), higher respiratory rate (p = 0.002), higher PCO2 (p < 0.001),higher lactic acid (p = 0.001), elevated WBCs (p = 0.010), hyponatremia (p < 0.001), higher CRP (p < 0.001), higher PESI (p = 0.001) and ESC score (p < 0.001), high sPESI risk (p = 0.016) and higher UA/Cr(p < 0.001) However, age, sex, platelets, low blood pressure, cardiopulmonary disease and heart ratedid not affect composite outcome. The gene discussed is CRP; the disease is thrombophilia.