In general, first-line Pembrolizumab monotherapy is considered in NSCLC with a PD-L1 TPS score of 50% or more (at least 50% of tumour cells express PD-L1), whereas a score of 1–49% leads to combination ICI and cytotoxic chemotherapy in non-driver mutation NSCLC [25,26] (Figure 2). This evidence concerns the gene CD274 and non-small cell lung carcinoma.