TNF and neoplasm: The same signalling molecule may have a multitude of functions depending on context, i.e., pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α) may lead to tumour growth initially and can also contribute to irAEs as indicated by recent studies on the role of TNF and the potentially protective effect of anti-TNFs as an approach to ameliorate irAEs and potentiate the efficacy of ICI [13,14,15,16].