Some studies have analyzed salivary IL-6 levels in patients not only with common oral pathologies [33], but also in systemic diseases such as polycystic ovary syndrome [34], bladder pain syndrome sleep disorders [35], in sepsis [29], Huntington’s disease [36], diabetes [37], in stroke [38], Hashimoto’s disease [39], and inflammatory diseases [40]. This evidence concerns the gene IL6 and diabetes mellitus.