Blood biomarkers, including apolipoprotein A1 (lower ApoA1 correlated with DAT deficit), C-reactive protein (CRP; markers of a proinflammatory state), uric acid (role as an antioxidant and free-radical scavenger), and vitamin D (neuroprotective effect in animal models), predicted prognosis for motor and non-motor symptoms in PD subtypes derived from the clinical features [48]. This evidence concerns the gene APOA1 and Parkinson disease.