The most important features from the DBN analysis were finally combined with the risk predictors from Shapley explanation analysis to extend the clinical impact of the APACHE-II score towards the development of a scoring index based on IL-6, IL-8, IL-1b and TNF during the admission of hospitalized COVID-19 patients in the ICU across different time intervals of the disease. The gene discussed is CXCL8; the disease is COVID-19.