Non-cellular components such as the extracellular matrix (ECM), ECM remodeling enzymes, e.g., matrix metalloproteinase (MMPs), tissue inhibitors of metalloproteinase (TIMPs), Lysyl oxidases (LOXs), and growth factors (e.g., vascular endothelial growth factor, transforming growth factor beta, and platelet derived growth factor) play a major role in abnormal growth, local invasion, and metastasis, thereby promoting cancer progression [8,9,10,11,12]. This evidence concerns the gene LOX and cancer.