Notably, accumulating evidence suggests that BAFF may contribute to some B-cell malignancies such as non-Hodgkin’s lymphoma, chronic lymphocytic leukemia and multiple myeloma and that the role of BAFF in these malignancies may lie in its aberrant expression and production in these circumstances [49,50,51]. This evidence concerns the gene TNFSF13B and non-Hodgkin lymphoma.