In adults, many parameters were evaluated for their prognostic value in ALF: peak TB level [17,42,43], transaminases [8,9,42], INR or PT [9,17,43,44,45], presence of grade III/IV HE [1,29,43,44,45], more than seven days to the onset of HE [9,45], age [8,17,45], serum creatinine [45], thrombocytopenia as a marker of multiple organ failure [3,46], high ammonia [8,17,26,27], high plasma lactate [17,47], actin-free Gc globulin [26,48,49,50,51,52], and serum phosphate [26,53,54]. The gene discussed is GC; the disease is Thrombocytopenia.