Acromegaly should be screened in hypertensive patients (with the measurement of insulin like growth factor 1) when they have clinical manifestations consistent with the diagnosis (a rectangular face, an enlarged, widened nose, prominent cheekbones, thickened lips, prognathism, maxillary, soft tissue overgrowth, and skeletal deformities...) [73]. The gene discussed is IGF1; the disease is acromegaly.