Moreover, some mutations (VHL, NF1, and RET) are associated to other tumors rather than PGL (for instance, RET is associated to multiple endocrine neoplasia, VHL to hemangioblastomas, etc.), while other mutations are associated with metastatic forms of PGL (SDHB, FH, and SLC25A11). This evidence concerns the gene VHL and multiple endocrine neoplasia.