PKD1 and autosomal dominant polycystic kidney disease: In addition, it has been recently proven that RhoA/ROCK pathway activation is promoted following the inactivation of PKD-1 via activation of proteins involved in cystogenesis [17,18], whereas ROCK inhibition reduces the activity of proteins involved in cystogenesis, which are upregulated in both PKD1-mutated cystic cells and cystic kidney tissue samples from ADPKD patients [17,18].