DNMT1 and skin neoplasm: We also confirmed our findings in the A431 human skin cancer cell line after GTPs treatment (10 and 20 μg/mL for 5 days), where GTPs treatment upregulated miR-29 expression to promote DNA demethylation and significantly decreased DNMT activity and increased TET activity, further strengthening our hypothesis of the influential role GTPs play in the epigenetic modifications involved in photocarcinogenesis.