The results demonstrated higher levels of Hcy, ICAM-1 and VCAM-1 in patients who died in hospital or during the 6 months after TBI than in survivors; a significant link was found between Hcy and cognition impairment according to MCA and MMSE, and cerebral hemodynamic status according to PI (p = 0.000 for all) [23]. This evidence concerns the gene ICAM1 and Cognitive impairment.