Eventually, for the first time our data display that in healthy mature blood cells there is a greater accumulation of large HERCs and that, in terms of absolute values, the large HERCs transcript amount profoundly differs being HERC2 expressed at a remarkably lower extent when compared to HERC1. Overall, these findings let surmise a putative role of both giant HERCs in the chronic phase of the CML. The gene discussed is HERC2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.