PNLIP and obesity due to melanocortin 4 receptor deficiency: The imbalance between calorie consumption and metabolic expenditure is a central factor in several cases of obesity, and reduction in the intake of energy dense fats may be useful to reduce weight; therefore, the suppression of energy intake by inhibiting the action of pancreatic lipase that splits triglycerides into absorbable glycerol and fatty acids could be a useful strategy [75].