For example, headaches are associated with elevated Tumor Necrosis Factor-α (TNF-α), Interleukin-10 (IL-10), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Interferon-α (IFN-α) levels [9,12,13]. The gene discussed is IL6; the disease is Headache.