ALDH7A1 and pyridoxine-dependent epilepsy: The mutation in the ALDH7A1 gene described above resulting in α-aminoadipic semialdehyde dehydrogenase deficiency is the most common cause of pyridoxine-dependent epilepsy, while other genetically determined causes of pyridoxine-dependent/responsive seizures to therapeutic administration of vitamin B6 can be distinguished [2,16,17,30].