In their use, cytokines and chemokines can be used as predictors of clinical symptoms and have diagnostic values, such as finding IP-10, IL-10, and IL-7 in asymptomatic COVID-19 patients that can help identify asymptomatic infections in close and suspected cases, as well as findings of IL-6, IL-7, IL-10, IL-18, G-CSF, M-CSF, MCP-1, MCP-3, IP-10, MIG, and MIP-1α are associated with COVID-19 severity [52,53]. This evidence concerns the gene IL18 and COVID-19.