Disruption of SIRT1 expression will disrupt cellular functionality due to the accumulation of oxidative stress, mitochondrial damage, and neuroinflammation that end in neurodegenerative diseases, one of which is also related to Alzheimer’s disease; impaired SIRT1 expression will cause neuronal inflammation and accumulation of Aβ plaques [136,141,142,143]. This evidence concerns the gene SIRT1 and neurodegenerative disease.