Advanced amyloidosis also results in lower glucose uptake in APP23, APP/P1, and AD-Aβ25–35 models in the cortex [178,179,180], as well as in the hippocampus, thalamus, and entorhinal cortex (APP23, APP/P1) [178,180], pointing to reduced glucose transport, which is in accordance to other studies [182]. Here, APP is linked to Alzheimer disease.