The relevance of recoverin antibodies in the development of cognitive dysfunction in our case series is unclear, but novel criteria suggest that their cognitive impairments may have an autoimmune origin, as we found indices of specific autoimmune indicators already mentioned, and brain MRIs indicated a chronic degenerative state after long-term inflammation with resulting brain atrophy and, lastly, elevated p-tau 181 and t-tau levels in the CSF as indices of axonal brain damage. Here, RCVRN is linked to Cognitive impairment.