MKI67 and neoplasm: This finding perfectly fits to the pro-tumorigenic effects of HELLS in promoting tumor cell growth, migration and in vivo tumorigenicity, described by Law et al., who also reported a correlation of HELLS with early onset age, direct liver invasion, venous invasion, advanced TNM stages, higher histological grade, Ki67-proliferation index, as well as with poorer overall survival and disease-free survival [19].