Consistent with previously published data both HELLS and FOXM1 were significantly overexpressed in HCC samples compared to non-tumorous liver tissue (Figure 1A (HELLS) and Figure S6B (FOXM1)) as well as in TP53 mutant compared to TP53 wt HCCs (Figure 1B (HELLS) and Figure S6C (FOXM1), while P21/CDKN1A was lower expressed in TP53 mutant HCCs compared to TP53 wt HCCs (Figure S6D). This evidence concerns the gene CDKN1A and hepatocellular carcinoma.