Hepatocyte DPP4 expression in obesity has been demonstrated to increase the level of soluble DPP4 in serum and promote visceral adipose tissue (VAT) inflammation and insulin resistance, suggesting that crosstalk between the liver and VAT can exacerbate metabolic disorder in the context of obesity [20]. The gene discussed is DPP4; the disease is obesity due to melanocortin 4 receptor deficiency.