CD8A and hepatocellular carcinoma: Regarding the induction of DPP4 via the circMET/miR-30-5p/Snail axis in HCC tissues, implantation of C57/BL/6 mice with circMET-transfected Hep1-6 cells was reported to induce an immunosuppressive tumor microenvironment with significant suppression of tumor-infiltrating CD8+ T cells [33].