This difference is mainly found in proteins functionally related to each pathology, for example: sCD44, HIF1A, ZMYM3 or PTPRC for CSF + LM in lymphoma and S100A9, TRAF3, KLK3, KLK2, PTPRC, among others, in the case of CSF + LM in leukemia (Table S7). The gene discussed is KLK2; the disease is leukemia.