Finally, within CSF + LM group, differential protein profiles were observed between leukemia and lymphoma (such as FCGR1, CR2, ABL1, PTPRC, SELP, ITGB1, COL9A3 or ITGAX), which could subtype the CSF + LM depending on the primary tumor (Figure 3). Here, COL9A3 is linked to neoplasm.