Furthermore, there was a significant activation of the PI3K/AKT pathway, integrin, TNFR2, TGF-β, B-cell activation and oxidative stress that correlated with development of BRAF inhibitor resistance, leptomeningeal progression and poor survival [62]; or even in the analysis of CSF in other pathologies such as Alzheimer’s disease, where the protein profile is characterized according to the stage of disease progression [63]. This evidence concerns the gene TNFRSF1B and early-onset autosomal dominant Alzheimer disease.