GSDMD and neoplasm: As shown in Figure 1C, the expression levels of some genes presented the same trends as the CNV alteration (elevated expression in amplification-gain, downregulated expression in deletion-loss in tumor), such as GSDMD, CASP3, PLCG1, and NLRP1, whereas a few genes showed opposite expression trends to the CNV alteration, including AIM2, NLRP3, TNF, and IL-6.