TP53 and hepatocellular carcinoma: As more and more mutant genes and epigenetic alterations associated with the occurrence and progression of HCC have been identified, the main focus has been on hepatitis viruses and apoptosis [8,9], including telomerase reverse transcriptase (TERT), tumor protein p53 (TP53), and Catenin Beta 1 (CTNNB1) [10,11].