CD8A and hepatocellular carcinoma: To further explore the potential prognostic significance of the combination of the pyroptosis score system and immune status in HCC, we identified three pyroptosis modification patterns with significantly different immune landscapes, characterized by differences in CD4+ T cells, CD8+ T cells, Th17 characteristics, overall cell proliferation, aneuploidy, changes in numbers of non-silent mutations per Mb, and immunoregulatory gene expression.