Among 364 tumor samples with mutation data, 53 (14.6%) experienced mutations of pyroptosis-related genes, where NLRP2 and NLRP3 exhibited the highest mutation frequencies, and AIM2, IL-18, IL-1B, IL-6, NLRP1, NOD1, PYCARD, TIRAP, TNF, CASP1, CASP5, CASP6, CASP9, GPX4, GSDMA, GSDME, PJVK, and SCAF11 had no mutations across all samples (Figure S1A). Here, CASP6 is linked to neoplasm.