In addition, IS2 and IS4 scored higher compared to IS3 and IS6 on all anti-tumor immunostimulatory cells, such as activated CD4+ T cells, activated CD8+ T cells, and natural killer cells (Figure 5B), as well as pro-tumor immunosuppressive cells, such as regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs) (Figure 5C). Here, CD8A is linked to neoplasm.