On the other hand, Yamashita indicated that EpCAM is a Wnt/β-catenin signaling target gene [28] and EpCAM-positive HCC cells exhibit activation of the Wnt/β-catenin signaling pathway, epithelial cell morphology, and high tumorigenicity, resulting in poor prognosis [29,30]. Here, EPCAM is linked to hepatocellular carcinoma.