In overt HCC, deregulated oncogenes, such as MET, catenin B1 (CTNNB1), MYC, and c-terminal cyclin D1 (CCND1), and tumor suppressor genes, including TP53, phosphatase, tensin homolog deleted on chromosome 10 (PTEN), cyclin-dependent kinase inhibitor 2A (CDKN2A), and cadherin 1 (CDH1), have been characterized through genetic and epigenetic analyses [3]. Here, CDKN2A is linked to hepatocellular carcinoma.