The relationship between fibroblasts, EMTs, and cancer stem cells has been well investigated in scirrhous HCC, in which tumors are abundant in the fibrous portion; Seok et al. suggested that the fibrous stromal component in HCC might contribute to the acquisition of EMT-related genes and overexpression of TGF-β signaling in HCC [11]. Here, TGFB1 is linked to hepatocellular carcinoma.