In a study of resected specimens, Wnt/β-catenin-positive HCC was reported to be around 30–40%, and OATP1B3-positive HCC recognized by the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI was reported to be around 15–20%, suggesting the possibility that a certain number of Wnt/β-catenin-positive, HNF4α-negative, FOXM1-positive HCC subsets exist. This evidence concerns the gene SLCO1B3 and hepatocellular carcinoma.