TNC and central nervous system cancer: ECM proteins, such as Hyaluronan, Tenascin C, Osteopontin, SPARC, and Laminin expression, are upregulated at the invasive edge of glioblastomas [43]; Vitronectin is expressed at the margins of gliomas and surrounds invaded tumor cells [54,56]; and Laminin is highly expressed at the borders between the tumor and normal brain tissue [57,58].