They are induced by exposure to Th2 cytokines like IL-4 and IL-13, anti-inflammatory cytokines IL-10 and TGF-β, glucocorticoids or tumor microenvironmental factors, and can be defined by CD163 and CD206 surface expression and increased production of IL-10 or Arg1 [37,42]. The gene discussed is TGFB1; the disease is neoplasm.