In addition, PC tumors secrete high levels of growth factors, cytokines and chemokines, including TGF-β, IL10 and CXCL2, which help recruit several immunosuppressive cells (myeloid-derived suppressor cells [MSDC] and regulatory T [Treg] cells) and pro-tumorigenic TAMs, both in the TME and in peripheral blood [54,55], thereby promoting tumor tolerance and evasion by suppressing the proinflammatory type 1 CD4+helper T (Th1) and CD8+ cytotoxic T cells [56]. This evidence concerns the gene CD8A and neoplasm.